Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells
Date
2015
Authors
Guo, R.
Zhou, S.
Li, Y.
Li, X.
Fan, L.
Voelcker, N.H.
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Journal article
Citation
ACS applied materials & interfaces, 2015; 7(43):23958-23966
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Abstract
A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
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Copyright 2015 American Chemical Society.