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Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

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dc.contributor.authorGuo, R.
dc.contributor.authorZhou, S.
dc.contributor.authorLi, Y.
dc.contributor.authorLi, X.
dc.contributor.authorFan, L.
dc.contributor.authorVoelcker, N.H.
dc.date.issued2015
dc.description.abstractA turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
dc.identifier.citationACS applied materials & interfaces, 2015; 7(43):23958-23966
dc.identifier.doi10.1021/acsami.5b06523
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.urihttps://hdl.handle.net/11541.2/116975
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.fundingMajor Research Plan of NSFC 21233003
dc.relation.fundingARC CE140100036
dc.relation.fundingKey Laboratory of Theoretical and Computational Photochemistry
dc.rightsCopyright 2015 American Chemical Society.
dc.source.urihttps://doi.org/10.1021/acsami.5b06523
dc.subjectcancer stem cells
dc.subjectdetection
dc.subjectFe3+
dc.subjectgraphene quantum dots
dc.subjectrhodamine B derivative
dc.titleRhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916015812001831

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