Actions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices

Date

1997

Authors

Ong, J.
Kerr, D.
Vaccher, C.
Berthelot, P.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

European Journal of Pharmacology, 1997; 329(2-3):133-136

Statement of Responsibility

Jennifer Ong, David I.B. Kerr, Claude Vaccher, Pascal Berthelot

Conference Name

DOI

10.1016/S0014-2999(97)00185-4

Abstract

In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.

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Dissertation Note

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Description

Short communication

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© 1997 Elsevier Science B.V.

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Published Version

https://doi.org/10.1016/s0014-2999(97)00185-4

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Persistent link to this record

http://hdl.handle.net/2440/5993