Actions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices

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dc.contributor.authorOng, J.
dc.contributor.authorKerr, D.
dc.contributor.authorVaccher, C.
dc.contributor.authorBerthelot, P.
dc.date.issued1997
dc.descriptionShort communication
dc.description.abstractIn rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.
dc.description.statementofresponsibilityJennifer Ong, David I.B. Kerr, Claude Vaccher, Pascal Berthelot
dc.identifier.citationEuropean Journal of Pharmacology, 1997; 329(2-3):133-136
dc.identifier.doi10.1016/S0014-2999(97)00185-4
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.orcidOng, J. [0000-0002-0958-460X]
dc.identifier.urihttp://hdl.handle.net/2440/5993
dc.language.isoen
dc.publisherElsevier BV
dc.rights© 1997 Elsevier Science B.V.
dc.source.urihttps://doi.org/10.1016/s0014-2999(97)00185-4
dc.subjectBaclofen: GABAB receptor agonist
dc.subjectThienyl baclofen analog
dc.subject2-Hydroxysaclofen
dc.subjectNeocortical slice, rat
dc.titleActions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices
dc.title.alternativeActions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices
dc.typeJournal article
pubs.publication-statusPublished

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