Adaptors as the regulators of HECT ubiquitin ligases
Date
2021
Authors
Shah, S.S.
Kumar, S.
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Journal article
Citation
Cell Death and Differentiation, 2021; 28(2):455-472
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Sonia Shalini Shah and Sharad Kumar
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Abstract
The HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of highly conserved enzymes involved in diverse cellular functions and pathological conditions. Characterised by a C-terminal HECT domain that accepts ubiquitin from E2 ubiquitin conjugating enzymes, these E3s regulate key signalling pathways. The activity and functional regulation of HECT E3s are controlled by several factors including post-translational modifications, inter- and intramolecular interactions and binding of co-activators and adaptor proteins. In this review, we focus on the regulation of HECT E3s by accessory proteins or adaptors and discuss various ways by which adaptors mediate their regulatory roles to affect physiological outcomes. We discuss common features that are conserved from yeast to mammals, regardless of the type of E3s as well as shed light on recent discoveries explaining some existing enigmas in the field.
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Link to a related website: https://doi.org/10.1038/s41418-021-00737-8, Correction
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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021, corrected publication 2021