Adaptors as the regulators of HECT ubiquitin ligases

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dc.contributor.authorShah, S.S.
dc.contributor.authorKumar, S.
dc.date.issued2021
dc.descriptionLink to a related website: https://doi.org/10.1038/s41418-021-00737-8, Correction
dc.description.abstractThe HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of highly conserved enzymes involved in diverse cellular functions and pathological conditions. Characterised by a C-terminal HECT domain that accepts ubiquitin from E2 ubiquitin conjugating enzymes, these E3s regulate key signalling pathways. The activity and functional regulation of HECT E3s are controlled by several factors including post-translational modifications, inter- and intramolecular interactions and binding of co-activators and adaptor proteins. In this review, we focus on the regulation of HECT E3s by accessory proteins or adaptors and discuss various ways by which adaptors mediate their regulatory roles to affect physiological outcomes. We discuss common features that are conserved from yeast to mammals, regardless of the type of E3s as well as shed light on recent discoveries explaining some existing enigmas in the field.
dc.description.statementofresponsibilitySonia Shalini Shah and Sharad Kumar
dc.identifier.citationCell Death and Differentiation, 2021; 28(2):455-472
dc.identifier.doi10.1038/s41418-020-00707-6
dc.identifier.issn1350-9047
dc.identifier.issn1476-5403
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]
dc.identifier.urihttp://hdl.handle.net/2440/129702
dc.language.isoen
dc.publisherSpringer
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1158366
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1103006
dc.rights© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021, corrected publication 2021
dc.source.urihttps://doi.org/10.1038/s41418-020-00707-6
dc.subjectAnimals
dc.subjectHumans
dc.subjectSaccharomyces cerevisiae
dc.subjectCalcium
dc.subjectUbiquitin-Conjugating Enzymes
dc.subjectUbiquitin-Protein Ligases
dc.subjectAdaptor Proteins, Signal Transducing
dc.subjectSaccharomyces cerevisiae Proteins
dc.subjectUbiquitin
dc.subjectSignal Transduction
dc.subjectProtein Binding
dc.titleAdaptors as the regulators of HECT ubiquitin ligases
dc.typeJournal article
pubs.publication-statusPublished

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