Cardiovascular health and retinal microvascular geometry in Australian 11-12 year-olds

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dc.contributor.authorLiu, M.
dc.contributor.authorLycett, K.
dc.contributor.authorWake, M.
dc.contributor.authorHe, M.
dc.contributor.authorKerr, J.A.
dc.contributor.authorSaffery, R.
dc.contributor.authorJuonala, M.
dc.contributor.authorOlds, T.
dc.contributor.authorDwyer, T.
dc.contributor.authorBurgner, D.P.
dc.contributor.authorWong, T.Y.
dc.date.issued2020
dc.description.abstractTraditional retinal microvascular parameters (smaller arteriolar and greater venular caliber) are associated with cardiovascular risk factors, pre-clinical vascular phenotypes and clinical cardiovascular events in adults.Although novel retinal microvascular geometric parameters showed analogous associations in adults, less is known whether these parameters are associated with cardiovascular health from childhood. In a populationbasedcross-sectional study in children (n = 1126, mean age 11.4 years, 50.3% girls), we examined associations of cardiovascular risk factors and pre-clinical arterial phenotypes with retinal geometric parameters.Cardiovascular parameters included body mass index (BMI), an inflammatory marker (GlycA), low-density lipoprotein and high-density lipoprotein (HDL) cholesterol, systolic (SBP) and diastolic blood pressure, large artery functional (pulse wave velocity, PWV and carotid arterial elasticity) and structural (carotid intima-media thickness) phenotypes. Retinal geometric parameters (fractal dimension (Df) and tortuosity) were quantified from retinal images. Multivariable regression models were performed and adjusted for potential confounders.Higher values for BMI, SBP and PWV showed weak associations with lower (i.e. worse) arteriolar but not venularDf (standardized mean difference (SMD) ranging from −0.07 to −0.09, 95% CIs −0.15 to −0.01). Higher HDL was associated with greater arteriolar Df (SMD 0.07, 95% CI 0.01 to 0.13). Only higher SBP was associated with higher (i.e. worse) arteriolar but not venular tortuosity (SMD 0.09, 95% CI 0.02 to 0.16). In generally healthy children, some risk factors and pre-clinical arterial phenotypes show small associations with retinal geometric parameters. In childhood, emerging relationships between microvascular parameters and cardiometabolic risk may be better described by retinal vascular caliber than by geometric parameters.
dc.description.statementofresponsibilityWei-Yeh Liao, Brodie J. Hand, Giuseppe Rinaldi, John G. Semmler, George M. Opie
dc.identifier.citationMicrovascular Research, 2020; 129(103966):1-4
dc.identifier.doi10.1016/j.mvr.2019.103966
dc.identifier.issn0026-2862
dc.identifier.issn1095-9319
dc.identifier.orcidHand, B.J. [0000-0002-9778-343X]
dc.identifier.orcidRinaldi, G. [0000-0001-9943-6215]
dc.identifier.orcidSemmler, J.G. [0000-0003-0260-8047]
dc.identifier.orcidOpie, G.M. [0000-0001-7771-7569]
dc.identifier.urihttps://hdl.handle.net/2440/147466
dc.language.isoen
dc.publisherAcademic Press
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101009
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1139723
dc.relation.granthttp://purl.org/au-research/grants/arc/DE230100022
dc.rightsCopyright 2019 Elsevier
dc.source.urihttps://ora.ox.ac.uk/objects/uuid:50a91594-da58-4831-8cf8-939de706c5e2/download_file?safe_filename=LiuetalAAM2019.pdf%26type_of_work=Journal+article
dc.subjectmicrocirculation
dc.subjectretinal micrvasculature
dc.subjectretinal vascular parameters
dc.subjectchildren
dc.subjectpopulation-based study
dc.subjectrisk factors
dc.subjectpre-clinical vascular phenotypes
dc.subjectElectromyography
dc.subjectEvoked Potentials, Motor
dc.subjecttranscranial magnetic stimulation; ageing; plasticity; primary motor cortex
dc.titleCardiovascular health and retinal microvascular geometry in Australian 11-12 year-olds
dc.typeJournal article
pubs.publication-statusPublished

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