Porous silicon as delivery system for poorly soluble drugs
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(Published version)
Date
2010
Authors
Wang, Feng
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thesis
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Abstract
This thesis presents the studies of porous silicon microparticles used as delivery vehicle for improvement of in vitro dissolution and in vivo absorption of poorly water-soluble drugs, i.e. indomethacin and celecoxib. The study outcomes provided significant insight into the factors influencing dissolution kinetics and demonstrated the importance of surface chemistry and pore geometry of porous silicon microparticles to physicochemical properties, dissolution and in vivo absorption performances of these poorly water-soluble drugs.
School/Discipline
University of South Australia Ian Wark Research Institute
Ian Wark Research Institute
Ian Wark Research Institute
Dissertation Note
Thesis (PhD)--University of South Australia, 2010
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Copyright 2010 Feng Wang
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EN-AUS
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506 0#$fstar $2Unrestricted online access