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Porous silicon as delivery system for poorly soluble drugs

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dc.contributor.authorWang, Feng
dc.contributor.schoolUniversity of South Australia Ian Wark Research Institute
dc.contributor.schoolIan Wark Research Institute
dc.date.issued2010
dc.descriptionEN-AUS
dc.description.abstractThis thesis presents the studies of porous silicon microparticles used as delivery vehicle for improvement of in vitro dissolution and in vivo absorption of poorly water-soluble drugs, i.e. indomethacin and celecoxib. The study outcomes provided significant insight into the factors influencing dissolution kinetics and demonstrated the importance of surface chemistry and pore geometry of porous silicon microparticles to physicochemical properties, dissolution and in vivo absorption performances of these poorly water-soluble drugs.
dc.description.dissertationThesis (PhD)--University of South Australia, 2010
dc.identifier.urihttps://hdl.handle.net/1959.8/103391
dc.language.isoen
dc.provenanceCopyright 2010 Feng Wang
dc.subjectphysicochemical properties;in vitro dissolution;in vivo absorption;in vitro correlation;in vivo correlation;320501 Pharmaceutical Sciences and Pharmacy;250199 Physical Chemistry not elsewhere classified;291804 Nanotechnology ;nano-porous structure;poorly soluble drugs
dc.subject.lcshDrugs
dc.subject.lcshPorous silicon
dc.titlePorous silicon as delivery system for poorly soluble drugs
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12146663670001831 13146689450001831 9915953299101831_53111925620001831.pdf
ror.mmsid9915953299101831

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