The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers

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dc.contributor.authorWong, S.
dc.contributor.authorHaqshenas, G.
dc.contributor.authorGowans, E.
dc.contributor.authorMacKenzie, J.
dc.date.issued2012
dc.description.abstractThe dengue virus membrane (M) protein is a key component of the mature virion. Here, we characterised the cellular behaviour of M using a recombinant protein construct to understand its inherent properties. Using confocal microscopy, we showed that M and its intracellular precursor, prM, localised to the endoplasmic reticulum. M protein was also detected on the cell surface and secreted, suggesting that M can enter the secretory pathway. In addition, cross-linking studies showed that M can form dimers and tetramers. These findings suggest that M behaves as a secretory protein analogous to the major envelope protein E.
dc.description.statementofresponsibilitySook-San Wonga, Gholamreza Haqshenas, Eric J. Gowans, Jason Mackenzie
dc.identifier.citationFEBS Letters, 2012; 586(7):1032-1037
dc.identifier.doi10.1016/j.febslet.2012.02.047
dc.identifier.issn0014-5793
dc.identifier.issn1873-3468
dc.identifier.orcidGowans, E. [0000-0002-4274-8311]
dc.identifier.urihttp://hdl.handle.net/2440/76007
dc.language.isoen
dc.publisherElsevier Science BV
dc.rightsCrown Copyright © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.febslet.2012.02.047
dc.subjectDengue
dc.subjectPrM
dc.subjectM Protein
dc.subjectLocalisation
dc.subjectEndoplasmic reticulum
dc.subjectOligomerisation
dc.titleThe dengue virus M protein localises to the endoplasmic reticulum and forms oligomers
dc.typeJournal article
pubs.publication-statusPublished

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