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Impact of Cardiovascular Imaging Results on Medication Use and Adherence: A Systematic Review and Meta-Analysis

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dc.contributor.authorAnokye, R.
dc.contributor.authorDalla Via, J.
dc.contributor.authorDimmock, J.
dc.contributor.authorJackson, B.
dc.contributor.authorSchultz, C.
dc.contributor.authorSchaeffer, M.
dc.contributor.authorDickson, J.M.
dc.contributor.authorBlekkenhorst, L.C.
dc.contributor.authorStanley, M.
dc.contributor.authorHodgson, J.M.
dc.contributor.authorLewis, J.R.
dc.date.issued2024
dc.description.abstractIntroduction Cardiovascular imaging results offer valuable information that can guide health decisions, but their impact on medication use and adherence is unclear. This systematic review and meta-analysis aimed to determine the downstream impact of cardiovascular imaging results on medication use and adherence. Methods Searches were conducted across databases, including MEDLINE, PsychINFO, EMBASE, and relevant references up to 2024. Data were extracted from studies comparing outcomes for individuals with diseased versus normal arteries and trials comparing outcomes for individuals who were provided imaging results versus those with no access to imaging results and analysed in 2023 and 2024. Pooled odds ratios (ORs) for outcomes were calculated. Results The analysis included 29 studies with 24 contributing data points. Initiation (OR:2.77;95% CI:1.82–4.20) and continuation (OR:2.06;95% CI:1.28–3.30) of lipid-lowering medications (LLMs), antihypertensives (OR:2.02;95% CI:1.76–2.33), and antiplatelets (OR:2.47;95% CI:1.68–3.64) were significantly higher in individuals with diseased arteries. The proportion of individuals on LLM increased by 2.7-fold in those with diseased arteries and 1.5-fold in those with normal arteries post-screening. The proportion on LLM increased by 4.2 times in the imaging group and 2.2 times in the "no imaging group" post-screening. There was a significant increase in LLM initiation (OR:2.37;95% CI: 1.17–4.79) in the imaging group, but medication continuation did not significantly differ between the imaging and "no imaging group". Discussion Cardiovascular imaging results can prompt initiation of medications, particularly lipid-lowering medications, reflecting a proactive response to identified risk factors. However, evidence regarding medication continuation is mixed, and further research is required.
dc.description.statementofresponsibilityReindolf Anokye, Jack Dalla Via, James Dimmock, Ben Jackson, Carl Schultz, Mie Schaeffer, Joanne M. Dickson, Lauren C. Blekkenhorst, Mandy Stanley, Jonathan M. Hodgson, Joshua R. Lewis
dc.identifier.citationAmerican Journal of Preventive Medicine, 2024; 67(4):606-617
dc.identifier.doi10.1016/j.amepre.2024.06.008
dc.identifier.issn0749-3797
dc.identifier.issn1873-2607
dc.identifier.urihttps://hdl.handle.net/2440/149322
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1172987
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1116973
dc.rights© 2024 The Author(s).Published by ElsevierInc. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.1016/j.amepre.2024.06.008
dc.subjectcardiovascular imaging results; medication use and adherence; systematic review
dc.titleImpact of Cardiovascular Imaging Results on Medication Use and Adherence: A Systematic Review and Meta-Analysis
dc.typeJournal article
pubs.publication-statusPublished

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