Reporting in rodent models of 'chemobrain': a systematic review assessing compliance with the ARRIVE guidelines
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(Accepted version)
Date
2021
Authors
George, R.
Semendric, I.
Bowley-Schubert, E.
Chivonivoni, C.
Warrender, A.
Whittaker, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Supportive Care in Cancer, 2021; 29(11):7073-7084
Statement of Responsibility
Rebecca P. George, Ines Semendric, Eleanor R. Bowley-Schubert, Christine T. Chivonivoni, Alexandra P. Warrender, Alexandra L. Whittaker
Conference Name
Abstract
Patients diagnosed with cancer are often plagued with debilitating side effects post-chemotherapy treatment. One such side effect is chemotherapy-induced cognitive impairment or ‘chemobrain’. Rodent models are commonly used to investigate pathogenesis and potential therapeutic strategies. However, concerns have been raised regarding inadequacies in reporting of animal studies rendering them unreliable and irreproducible. The aim of this systematic review was to assess compliance with the ARRIVE reporting guidelines in peer-reviewed publications evaluating chemotherapy-induced cognitive changes in rodent models, and to determine if the introduction of the ARRIVE guidelines has improved quality of reporting. A comprehensive search was conducted to identify relevant peer-reviewed publications. Ninety-seven studies met the eligibility criteria, and publication compliance with the ARRIVE guideline reporting was assessed. No studies achieved full adherence with the ARRIVE guidelines. Furthermore, no significant improvement was demonstrated in the overall compliance score post-ARRIVE. Given the lack of standardisation of animal models in this research area, these results pose particular threat to future progress and translation of findings in this area of research. These results highlight the need for stricter adherence to the ARRIVE guidelines by journal editors and reviewers. Animal Ethics Committees also have an important educative role in improving knowledge and awareness of the guidelines amongst researchers.
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Dissertation Note
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Published online: 2 June 2021
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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021