Reporting in rodent models of 'chemobrain': a systematic review assessing compliance with the ARRIVE guidelines

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dc.contributor.authorGeorge, R.
dc.contributor.authorSemendric, I.
dc.contributor.authorBowley-Schubert, E.
dc.contributor.authorChivonivoni, C.
dc.contributor.authorWarrender, A.
dc.contributor.authorWhittaker, A.
dc.date.issued2021
dc.descriptionPublished online: 2 June 2021
dc.description.abstractPatients diagnosed with cancer are often plagued with debilitating side effects post-chemotherapy treatment. One such side effect is chemotherapy-induced cognitive impairment or ‘chemobrain’. Rodent models are commonly used to investigate pathogenesis and potential therapeutic strategies. However, concerns have been raised regarding inadequacies in reporting of animal studies rendering them unreliable and irreproducible. The aim of this systematic review was to assess compliance with the ARRIVE reporting guidelines in peer-reviewed publications evaluating chemotherapy-induced cognitive changes in rodent models, and to determine if the introduction of the ARRIVE guidelines has improved quality of reporting. A comprehensive search was conducted to identify relevant peer-reviewed publications. Ninety-seven studies met the eligibility criteria, and publication compliance with the ARRIVE guideline reporting was assessed. No studies achieved full adherence with the ARRIVE guidelines. Furthermore, no significant improvement was demonstrated in the overall compliance score post-ARRIVE. Given the lack of standardisation of animal models in this research area, these results pose particular threat to future progress and translation of findings in this area of research. These results highlight the need for stricter adherence to the ARRIVE guidelines by journal editors and reviewers. Animal Ethics Committees also have an important educative role in improving knowledge and awareness of the guidelines amongst researchers.
dc.description.statementofresponsibilityRebecca P. George, Ines Semendric, Eleanor R. Bowley-Schubert, Christine T. Chivonivoni, Alexandra P. Warrender, Alexandra L. Whittaker
dc.identifier.citationSupportive Care in Cancer, 2021; 29(11):7073-7084
dc.identifier.doi10.1007/s00520-021-06312-8
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.orcidGeorge, R. [0000-0003-3625-3598]
dc.identifier.orcidSemendric, I. [0000-0002-7099-929X]
dc.identifier.orcidBowley-Schubert, E. [0000-0002-0184-4251]
dc.identifier.orcidWhittaker, A. [0000-0001-9011-8296]
dc.identifier.urihttp://hdl.handle.net/2440/131059
dc.language.isoen
dc.publisherSpringer-Verlag
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140072
dc.rights© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021
dc.source.urihttps://doi.org/10.1007/s00520-021-06312-8
dc.subjectChemobrain; CICI; Cognitive impairment; ARRIVE; Reporting guidelines
dc.titleReporting in rodent models of 'chemobrain': a systematic review assessing compliance with the ARRIVE guidelines
dc.typeJournal article
pubs.publication-statusPublished

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