A naturalistic study of the measurement of seizure adequacy in electroconvulsive therapy

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dc.contributor.authorEdwards, M.
dc.contributor.authorKoopowitz, L.
dc.contributor.authorHarvey, E.
dc.date.issued2003
dc.description.abstract<h4>Objective</h4>The aim of this study was to assess an electroconvulsive therapy (ECT) rating scale by studying the intraictal electroencephalograph parameters induced by the seizure, and determine the clinical utility of such a scale in terms of time, application and ease of use.<h4>Method</h4>This naturalistic study of 55 depressed patients over a 2-year period examined specific parameters of the intraictal electroencephalograph seizure morphology and computer printout, and their association with overall clinical outcome. The rating scale was developed and evaluated in terms of clinical reliability and ease of use.<h4>Results</h4>Overall, 1076 individual ECT treatments were given. Using multiple regression analysis, overall seizure adequacy correlated most closely with abrupt seizure endpoint, a high amplitude rhythmic spike and wave phase of >13 s, a seizure energy index of >1000 u, and an electroencephalograph seizure length of > 24 s. "Adequate" overall ratings as determined by the rating scale were shown to correlate significantly with overall clinical improvement. The rating scale had extremely high interrater and test-retest reliability; and was relatively easy to use and time efficient.<h4>Conclusions</h4>The use of the rating scale has the potential to help clinicians optimize ECT. While not perfect in any sense, it still gives clinicians good predictive qualities when used as a clinical guide. It is important that larger studies look at all the potential variables that may interact with seizure adequacy and clinical outcome.
dc.description.statementofresponsibilityEdwards, Mark; Koopowitz, Leslie F.; Harvey, Eileen J.
dc.identifier.citationAustralian and New Zealand Journal of Psychiatry, 2003; 37(3):312-318
dc.identifier.doi10.1046/j.1440-1614.2003.01183.x
dc.identifier.issn0004-8674
dc.identifier.issn1440-1614
dc.identifier.urihttp://hdl.handle.net/2440/6313
dc.language.isoen
dc.publisherBlackwell Science Asia
dc.source.urihttps://doi.org/10.1046/j.1440-1614.2003.01183.x
dc.subjectHumans
dc.subjectSeizures
dc.subjectElectroencephalography
dc.subjectSeverity of Illness Index
dc.subjectRegression Analysis
dc.subjectMental Disorders
dc.subjectElectroconvulsive Therapy
dc.subjectTime Factors
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleA naturalistic study of the measurement of seizure adequacy in electroconvulsive therapy
dc.typeJournal article
pubs.publication-statusPublished

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