Protein-induced modifications in crystal morphology of a hydrogen-bonded organic framework

Date

2023

Authors

Flint, K.L.
Evans, J.D.
Carraro, F.
Renner, S.
Linder-Patton, O.M.
Amenitsch, H.
Falconer, R.J.
White, N.G.
Sumby, C.J.
Falcaro, P.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Journal of Materials Chemistry A, 2023; 11(42):23026-23033

Statement of Responsibility

Kate L. Flint, Jack D. Evans, Francesco Carraro, Simon Renner, Oliver M. Linder-Patton, Heinz Amenitsch, Robert J. Falconer, Nicholas G. White, Christopher J. Sumby, Paolo Falcaro and Christian J. Doonan

Conference Name

Abstract

In this work, we studied the encapsulation of a range of proteins in a hydrogen-bonded organic framework (HOF) comprised of a tetraamidinium cation and diazobenzene-based dicarboxylate anion. We explore the use of external stimuli: light and temperature to modulate HOF crystal growth and size. In particular, we found photo-isomerisation can be used to control the concentration of the trans-azobenzene building block that contributes to HOF formation. When HOF growth was slowed sufficiently, deformation of the crystals and ultimately multicrystal aggregates were observed in the presence of some proteins. We propose that the extent of crystal deformation, consistent with better protein association, may be governed by differences in the type and strength of interactions between proteins and the surface of the growing HOF crystals.

School/Discipline

Dissertation Note

Provenance

Description

Access Status

Rights

© The Royal Society of Chemistry 2023

License

Call number

Persistent link to this record