Protein-induced modifications in crystal morphology of a hydrogen-bonded organic framework

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dc.contributor.authorFlint, K.L.
dc.contributor.authorEvans, J.D.
dc.contributor.authorCarraro, F.
dc.contributor.authorRenner, S.
dc.contributor.authorLinder-Patton, O.M.
dc.contributor.authorAmenitsch, H.
dc.contributor.authorFalconer, R.J.
dc.contributor.authorWhite, N.G.
dc.contributor.authorSumby, C.J.
dc.contributor.authorFalcaro, P.
dc.contributor.authorDoonan, C.J.
dc.date.issued2023
dc.description.abstractIn this work, we studied the encapsulation of a range of proteins in a hydrogen-bonded organic framework (HOF) comprised of a tetraamidinium cation and diazobenzene-based dicarboxylate anion. We explore the use of external stimuli: light and temperature to modulate HOF crystal growth and size. In particular, we found photo-isomerisation can be used to control the concentration of the trans-azobenzene building block that contributes to HOF formation. When HOF growth was slowed sufficiently, deformation of the crystals and ultimately multicrystal aggregates were observed in the presence of some proteins. We propose that the extent of crystal deformation, consistent with better protein association, may be governed by differences in the type and strength of interactions between proteins and the surface of the growing HOF crystals.
dc.description.statementofresponsibilityKate L. Flint, Jack D. Evans, Francesco Carraro, Simon Renner, Oliver M. Linder-Patton, Heinz Amenitsch, Robert J. Falconer, Nicholas G. White, Christopher J. Sumby, Paolo Falcaro and Christian J. Doonan
dc.identifier.citationJournal of Materials Chemistry A, 2023; 11(42):23026-23033
dc.identifier.doi10.1039/d3ta04707e
dc.identifier.issn2050-7488
dc.identifier.issn2050-7496
dc.identifier.orcidFlint, K.L. [0000-0002-9043-8369]
dc.identifier.orcidEvans, J.D. [0000-0001-9521-2601]
dc.identifier.orcidLinder-Patton, O.M. [0000-0002-4173-9931]
dc.identifier.orcidFalconer, R.J. [0000-0002-9912-9036]
dc.identifier.orcidSumby, C.J. [0000-0002-9713-9599]
dc.identifier.urihttps://hdl.handle.net/2440/140440
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200102411
dc.relation.granthttp://purl.org/au-research/grants/arc/DE220100163
dc.rights© The Royal Society of Chemistry 2023
dc.source.urihttps://doi.org/10.1039/d3ta04707e
dc.subjectprotein encapsulation; hydrogen-bonded organic framework (HOF)
dc.titleProtein-induced modifications in crystal morphology of a hydrogen-bonded organic framework
dc.typeJournal article
pubs.publication-statusPublished online

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