Continuous production of oxytetracycline in fluidized bed bioreactor by immobilized cells of streptomyces varsoviensis MTCC-1537: effect of dilution and glucose loading rates

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dc.contributor.authorJetty, A.
dc.contributor.authorPotumarthi, R.
dc.contributor.authorRao, A.G.
dc.contributor.authorRao, B.S.
dc.contributor.authorRamakrishna, S.V.
dc.date.issued2009
dc.description.abstractOxytetracycline (OT) production using glutaraldehyde cross-linked calcium alginate immobilized cells of Streptomyces varsoviensis in continuous fluidized bed reactor (FBR) was investigated. Initially, batch experiments were carried in stirred tank reactor (STR) and FBR using calcium alginate immobilized cells. Higher OT production of 0.45 gm/L was achieved by FBR when compared with 0.33 g/L of OT in STR. All subsequent studies were carried out in continuous mode of operation in FBR. During 21 days of operation, effect of glucose concentration and different dilution rates were studied. A maximum of 0.75 g/L OT was achieved in the medium having 10 g/L of glucose concentration. The highest OT concentration of 0.92 g/L and the highest yield of OT with respect to biomass at 0.1713 g/g were obtained at the dilution rate of 0.25 day-1.
dc.description.statementofresponsibilityAnnapurna Jetty, Ravichandra Potumarthi, A. Gangagni Rao, B. Sarva Rao, S. V. Ramakrishna
dc.identifier.citationApplied Biochemistry and Biotechnology, 2009; 159(2):579-588
dc.identifier.doi10.1007/s12010-009-8623-y
dc.identifier.issn0273-2289
dc.identifier.issn1559-0291
dc.identifier.urihttp://hdl.handle.net/2440/86932
dc.language.isoen
dc.publisherHumana Press
dc.rights© Humana Press 2009
dc.source.urihttp://dx.doi.org/10.1007/s12010-009-8623-y
dc.subjectYield kinetics
dc.subjectCross-linking
dc.subjectAntibiotics production
dc.subjectGlucose concentration
dc.subjectContinuous process
dc.subjectStirred tank reactor
dc.titleContinuous production of oxytetracycline in fluidized bed bioreactor by immobilized cells of streptomyces varsoviensis MTCC-1537: effect of dilution and glucose loading rates
dc.typeJournal article
pubs.publication-statusPublished

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