Enzyme activity assays within microstructured optical fibers enabled by automated alignment
Date
2012
Authors
Warren-Smith, S.
Nie, G.
Schartner, E.
Salamonsen, L.
Monro, T.
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Journal article
Citation
Biomedical Optics Express, 2012; 3(12):1-10
Statement of Responsibility
Stephen C. Warren-Smith, Guiying Nie, Erik P. Schartner, Lois A. Salamonsen, and Tanya M. Monro
Conference Name
Abstract
A fluorescence-based enzyme activity assay has been demonstrated within a small-core microstructured optical fiber (MOF) for the first time. To achieve this, a reflection-based automated alignment system has been developed, which uses feedback and piezoelectric actuators to maintain optical alignment. The auto-alignment system provides optical stability for the time required to perform an activity assay. The chosen assay is based on the enzyme proprotein convertase 5/6 (PC6) and has important applications in women's health.
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© 2012 OSA