Enzyme activity assays within microstructured optical fibers enabled by automated alignment

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dc.contributor.authorWarren-Smith, S.
dc.contributor.authorNie, G.
dc.contributor.authorSchartner, E.
dc.contributor.authorSalamonsen, L.
dc.contributor.authorMonro, T.
dc.date.issued2012
dc.description.abstractA fluorescence-based enzyme activity assay has been demonstrated within a small-core microstructured optical fiber (MOF) for the first time. To achieve this, a reflection-based automated alignment system has been developed, which uses feedback and piezoelectric actuators to maintain optical alignment. The auto-alignment system provides optical stability for the time required to perform an activity assay. The chosen assay is based on the enzyme proprotein convertase 5/6 (PC6) and has important applications in women's health.
dc.description.statementofresponsibilityStephen C. Warren-Smith, Guiying Nie, Erik P. Schartner, Lois A. Salamonsen, and Tanya M. Monro
dc.identifier.citationBiomedical Optics Express, 2012; 3(12):1-10
dc.identifier.doi10.1364/BOE.3.003304
dc.identifier.issn2156-7085
dc.identifier.issn2156-7085
dc.identifier.orcidWarren-Smith, S. [0000-0002-2612-6344]
dc.identifier.orcidSchartner, E. [0000-0003-1669-4302]
dc.identifier.urihttp://hdl.handle.net/2440/74884
dc.language.isoen
dc.publisherOptical Society of America
dc.rights© 2012 OSA
dc.source.urihttps://doi.org/10.1364/boe.3.003304
dc.subject(060.2370) Fiber optics sensors
dc.subject(060.4005) Microstructured fibers
dc.subject(280.1415) Biological sensing and sensors
dc.titleEnzyme activity assays within microstructured optical fibers enabled by automated alignment
dc.typeJournal article
pubs.publication-statusPublished

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