Association of perceived stress with health status outcomes in patients with peripheral artery disease

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dc.contributor.authorMalik, A.O.
dc.contributor.authorPoghni Peri-Okonny,
dc.contributor.authorGosch, K.
dc.contributor.authorThomas, M.B.
dc.contributor.authorMena-Hurtado, C.
dc.contributor.authorHiatt, W.
dc.contributor.authorAronow, H.D.
dc.contributor.authorJones, P.G.
dc.contributor.authorProvance, J.
dc.contributor.authorLabrosciano, C.
dc.contributor.authorJelani, Q.U.A.
dc.contributor.authorSpertus, J.A.
dc.contributor.authorSmolderen, K.G.
dc.date.issued2021
dc.description.abstractObjective: To assess association of chronic self-perceived stress with health status outcomes of patients with peripheral artery disease. Methods: The PORTRAIT study is a prospective registry that enrolled 1275 patients with symptoms of peripheral artery disease across 16-sites in US, Netherlands, and Australia from June 2011 to December 2015. Demographics, comorbidities and diagnostic information was abstracted from chart review. Self-perceived stress was assessed using the 4-item perceived stress scale at baseline, 3- and 6-month follow-up. Scores range from 0 to 16 with higher scores indicating greater stress. Sum scores were calculated at each time point and averaged to quantify average exposure to stress from enrollment through 6 months. Disease-specific health status were assessed at baseline and 12-months using the peripheral artery disease questionnaire summary score. Results: The mean age of the analytical cohort (n = 1060) was 67.7 ± 9.3 years, 37.1% were females, and 82.3% were white. Comorbidities were highly prevalent with 80.9% having hypertension, 32.6% having diabetes, and 36.4% being smokers. In models adjusted for demographics, comorbidities, disease severity and socioeconomic status, having a higher average stress score was associated with poorer recovery (from baseline) in peripheral artery disease questionnaire summary score at 12-months (— 1.4 points per +1-point increase in averaged 4-point perceived stress score, 95% CI -2.1, — 0.6 p < 0.001). Conclusion: In patients with peripheral artery disease, experiencing higher chronic stress throughout the 6- months following their diagnosis, was independently associated with poorer recovery in 12-month diseasespecific health status outcomes. (ClinicalTrial.gov identifier: NCT01419080).
dc.description.statementofresponsibilityAli O. Malik, Poghni Peri-Okonny, Kensey Gosch, Merrill B. Thomas, Carlos Mena-Hurtado, William Hiatt, Herbert D. Aronow, Phillip G. Jones, Jeremy Provance, Clementine Labrosciano, Qurat-ul-ain Jelani, John A. Spertus, Kim G. Smolderen
dc.identifier.citationJournal of Psychosomatic Research, 2021; 140:110313-1-110313-7
dc.identifier.doi10.1016/j.jpsychores.2020.110313
dc.identifier.issn0022-3999
dc.identifier.issn1879-1360
dc.identifier.orcidLabrosciano, C. [0000-0001-5995-4616]
dc.identifier.orcidSpertus, J.A. [0000-0001-9485-0652] [0000-0002-2839-2611]
dc.identifier.urihttps://hdl.handle.net/2440/146212
dc.language.isoen
dc.publisherElsevier BV
dc.rights© 2020 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.jpsychores.2020.110313
dc.subjectChronic stress; Health status; Peripheral artery disease
dc.subject.meshHumans
dc.subject.meshSeverity of Illness Index
dc.subject.meshRegistries
dc.subject.meshCohort Studies
dc.subject.meshProspective Studies
dc.subject.meshStress, Psychological
dc.subject.meshHealth Status
dc.subject.meshAged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshPeripheral Arterial Disease
dc.titleAssociation of perceived stress with health status outcomes in patients with peripheral artery disease
dc.typeJournal article
pubs.publication-statusPublished

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