Effects of magnesium deficiency-more than skin deep
Date
2014
Authors
Chandrasekaran, N.C.
Weir, C.
Alfraji, S.
Grice, J.
Roberts, M.S.
Barnard, R.T.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Experimental Biology and Medicine, 2014; 239(10):1280-1291
Statement of Responsibility
Conference Name
Abstract
Dead Sea and magnesium salt therapy are two of the oldest forms of treatment for skin disease and several other disorders, supported by a body of largely anecdotal evidence. In this paper we review possible pathways for penetration of magnesium ions through the epidermis to reach the circulation, in turn replenishing cellular magnesium levels. We also discuss mechanisms for intercellular movement of magnesium ions and possible mechanisms for the interaction between magnesium ions and inflammatory mediators. Upon addition of magnesium ions in vitro, the expression of inflammatory mediators such as tumour necrosis factor α (TNFα) and nuclear factor kβ (NFκβ) is down regulated. Dysregulation of these and other inflammatory mediators has been linked to several inflammatory disorders, including asthma, arthritis, atherosclerosis and neuroinflammation
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2014 by the Society for Experimental Biology and Medicine