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Effects of magnesium deficiency-more than skin deep

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dc.contributor.authorChandrasekaran, N.C.
dc.contributor.authorWeir, C.
dc.contributor.authorAlfraji, S.
dc.contributor.authorGrice, J.
dc.contributor.authorRoberts, M.S.
dc.contributor.authorBarnard, R.T.
dc.date.issued2014
dc.description.abstractDead Sea and magnesium salt therapy are two of the oldest forms of treatment for skin disease and several other disorders, supported by a body of largely anecdotal evidence. In this paper we review possible pathways for penetration of magnesium ions through the epidermis to reach the circulation, in turn replenishing cellular magnesium levels. We also discuss mechanisms for intercellular movement of magnesium ions and possible mechanisms for the interaction between magnesium ions and inflammatory mediators. Upon addition of magnesium ions in vitro, the expression of inflammatory mediators such as tumour necrosis factor α (TNFα) and nuclear factor kβ (NFκβ) is down regulated. Dysregulation of these and other inflammatory mediators has been linked to several inflammatory disorders, including asthma, arthritis, atherosclerosis and neuroinflammation
dc.identifier.citationExperimental Biology and Medicine, 2014; 239(10):1280-1291
dc.identifier.doi10.1177/1535370214537745
dc.identifier.issn1535-3702
dc.identifier.issn1535-3699
dc.identifier.urihttps://hdl.handle.net/11541.2/114636
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.fundingCancer Council
dc.relation.fundingNHMRC
dc.relation.fundingUniversity of Queensland
dc.rightsCopyright 2014 by the Society for Experimental Biology and Medicine
dc.source.urihttps://doi.org/10.1177/1535370214537745
dc.subjectinflammation a ‡ magnesium
dc.subjectskin
dc.titleEffects of magnesium deficiency-more than skin deep
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915913913201831

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