Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3? and repression of the human VEGF promoter
Date
2005
Authors
Coles, L.
Lambrusco, L.
Burrows, J.
Hunter, J.
Diamond, P.
Bert, A.
Vadas, M.
Goodall, G.
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Journal article
Citation
FEBS Letters, 2005; 579(24):5372-5378
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Leeanne S. Coles, Lidia Lambrusco, Julie Burrows, Julie Hunter, Peter Diamond, Andrew G. Bert, Mathew A. Vadas and Gregory J. Goodall
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Abstract
The hypoxia responsive region (HRR) of the VEGF promoter plays a key role in regulating VEGF expression. We found that the cold shock domain (Y-box) repressor proteins, dbpA and dbpB/YB-1, bind distinct strands of the human VEGF HRR. We find both dbpA and dbpB are phosphorylated by ERK2 and GSK3beta in vitro, and the binding of dbpB to single-strand VEGF HRR DNA is regulated by this phosphorylation. These findings suggest the ERK/MAPK and PI3K pathways may regulate VEGF expression in part through regulating the action of these repressor proteins.
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Copyright © 2005 Federation of European Biochemical Societies Published by Elsevier B.V.