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Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3? and repression of the human VEGF promoter

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dc.contributor.authorColes, L.
dc.contributor.authorLambrusco, L.
dc.contributor.authorBurrows, J.
dc.contributor.authorHunter, J.
dc.contributor.authorDiamond, P.
dc.contributor.authorBert, A.
dc.contributor.authorVadas, M.
dc.contributor.authorGoodall, G.
dc.date.issued2005
dc.description.abstractThe hypoxia responsive region (HRR) of the VEGF promoter plays a key role in regulating VEGF expression. We found that the cold shock domain (Y-box) repressor proteins, dbpA and dbpB/YB-1, bind distinct strands of the human VEGF HRR. We find both dbpA and dbpB are phosphorylated by ERK2 and GSK3beta in vitro, and the binding of dbpB to single-strand VEGF HRR DNA is regulated by this phosphorylation. These findings suggest the ERK/MAPK and PI3K pathways may regulate VEGF expression in part through regulating the action of these repressor proteins.
dc.description.statementofresponsibilityLeeanne S. Coles, Lidia Lambrusco, Julie Burrows, Julie Hunter, Peter Diamond, Andrew G. Bert, Mathew A. Vadas and Gregory J. Goodall
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506085/description#description
dc.identifier.citationFEBS Letters, 2005; 579(24):5372-5378
dc.identifier.doi10.1016/j.febslet.2005.08.075
dc.identifier.issn0014-5793
dc.identifier.issn1873-3468
dc.identifier.orcidGoodall, G. [0000-0003-1294-0692]
dc.identifier.urihttp://hdl.handle.net/2440/17481
dc.language.isoen
dc.publisherElsevier Science BV
dc.relation.grantNHMRC
dc.rightsCopyright © 2005 Federation of European Biochemical Societies Published by Elsevier B.V.
dc.source.urihttps://doi.org/10.1016/j.febslet.2005.08.075
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectGlycogen Synthase Kinase 3
dc.subjectMitogen-Activated Protein Kinase 1
dc.subjectVascular Endothelial Growth Factor A
dc.subjectDNA
dc.subjectBase Sequence
dc.subjectPhosphorylation
dc.subjectMolecular Sequence Data
dc.subjectPromoter Regions, Genetic
dc.subjectGlycogen Synthase Kinase 3 beta
dc.titlePhosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3? and repression of the human VEGF promoter
dc.typeJournal article
pubs.publication-statusPublished

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