A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
Date
2002
Authors
Andersson, P.
McGuire, J.
Rubio, C.
Gradin, K.
Whitelaw, M.
Pettersson, S.
Hanberg, A.
Poellinger, L.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Proceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-9995
Statement of Responsibility
Patrik Andersson, Jacqueline McGuire, Carlos Rubio, Katarina Gradin, Murray L. Whitelaw, Sven Pettersson, Annika Hanberg, and Lorenz Poellinger
Conference Name
Abstract
The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.
School/Discipline
Dissertation Note
Provenance
Description
Published online before print July 9, 2002
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Rights
Copyright © 2002 by the National Academy of Sciences