A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

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dc.contributor.authorAndersson, P.
dc.contributor.authorMcGuire, J.
dc.contributor.authorRubio, C.
dc.contributor.authorGradin, K.
dc.contributor.authorWhitelaw, M.
dc.contributor.authorPettersson, S.
dc.contributor.authorHanberg, A.
dc.contributor.authorPoellinger, L.
dc.contributor.organisationCentre for the Molecular Genetics of Development
dc.date.issued2002
dc.descriptionPublished online before print July 9, 2002
dc.description.abstractThe dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.
dc.description.statementofresponsibilityPatrik Andersson, Jacqueline McGuire, Carlos Rubio, Katarina Gradin, Murray L. Whitelaw, Sven Pettersson, Annika Hanberg, and Lorenz Poellinger
dc.identifier.citationProceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-9995
dc.identifier.doi10.1073/pnas.152706299
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/2440/28127
dc.language.isoen
dc.publisherNatl Acad Sciences
dc.rightsCopyright © 2002 by the National Academy of Sciences
dc.source.urihttp://www.pnas.org/content/99/15/9990
dc.subjectLiver
dc.subjectThymus Gland
dc.subjectCHO Cells
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectMice, Inbred CBA
dc.subjectMice
dc.subjectIntestinal Neoplasms
dc.subjectStomach Neoplasms
dc.subjectCytochrome P-450 CYP1A1
dc.subjectReceptors, Aryl Hydrocarbon
dc.subjectRecombinant Proteins
dc.subjectCarcinogens
dc.subjectCloning, Molecular
dc.subjectTransfection
dc.subjectGene Expression Regulation, Developmental
dc.subjectCricetinae
dc.subjectMale
dc.subjectPolychlorinated Dibenzodioxins
dc.titleA constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
dc.typeJournal article
pubs.publication-statusPublished

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