Biomolecular engineering of virus-like particles aided by computational chemistry methods
Date
2015
Authors
Zhang, L.
Lua, L.
Middelberg, A.
Sun, Y.
Connors, N.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Chemical Society Reviews, 2015; 44(23):8608-8618
Statement of Responsibility
Lin Zhang, Linda H.L. Lua, Anton P. J. Middelberg, Yan Sun and Natalie K. Connors
Conference Name
Abstract
Virus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both innate and adaptive immune responses, due to their particulate structure enabling uptake by antigen presenting cells. These characteristics have led to successful development of VLP-vaccine products, and will ensure their vast potential in years to come. Future success of VLP therapeutic products will be determined by advances in their bioengineering, and also by the development of tools to design for their stability, function and application. This review focuses on approaches for VLP assembly in controlled chemical environments in vivo and in vitro, and the application of computational tools for improved chemical sequence design, and fundamental understanding of assembly.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
This journal is ©The Royal Society of Chemistry 2015