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Biomolecular engineering of virus-like particles aided by computational chemistry methods

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dc.contributor.authorZhang, L.
dc.contributor.authorLua, L.
dc.contributor.authorMiddelberg, A.
dc.contributor.authorSun, Y.
dc.contributor.authorConnors, N.
dc.date.issued2015
dc.description.abstractVirus-like particles (VLPs) are repetitive organizations of viral proteins assembled in an appropriate physicochemical environment. VLPs can stimulate both innate and adaptive immune responses, due to their particulate structure enabling uptake by antigen presenting cells. These characteristics have led to successful development of VLP-vaccine products, and will ensure their vast potential in years to come. Future success of VLP therapeutic products will be determined by advances in their bioengineering, and also by the development of tools to design for their stability, function and application. This review focuses on approaches for VLP assembly in controlled chemical environments in vivo and in vitro, and the application of computational tools for improved chemical sequence design, and fundamental understanding of assembly.
dc.description.statementofresponsibilityLin Zhang, Linda H.L. Lua, Anton P. J. Middelberg, Yan Sun and Natalie K. Connors
dc.identifier.citationChemical Society Reviews, 2015; 44(23):8608-8618
dc.identifier.doi10.1039/c5cs00526d
dc.identifier.issn0306-0012
dc.identifier.issn1460-4744
dc.identifier.urihttp://hdl.handle.net/2440/110068
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.grantARC
dc.rightsThis journal is ©The Royal Society of Chemistry 2015
dc.source.urihttps://doi.org/10.1039/c5cs00526d
dc.subjectVirion; computational biology
dc.titleBiomolecular engineering of virus-like particles aided by computational chemistry methods
dc.typeJournal article
pubs.publication-statusPublished

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