Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease
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2020
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Barthelson, K.
Newman, M.
Lardelli, M.
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Journal of Alzheimer's Disease Reports, 2020; 4(1):123-140
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Karissa Barthelson, Morgan Newman and Michael Lardelli
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Abstract
Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
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© 2020 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).