Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease

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dc.contributor.authorBarthelson, K.
dc.contributor.authorNewman, M.
dc.contributor.authorLardelli, M.
dc.date.issued2020
dc.description.abstractSortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
dc.description.statementofresponsibilityKarissa Barthelson, Morgan Newman and Michael Lardelli
dc.identifier.citationJournal of Alzheimer's Disease Reports, 2020; 4(1):123-140
dc.identifier.doi10.3233/ADR-200177
dc.identifier.issn2542-4823
dc.identifier.issn2542-4823
dc.identifier.orcidBarthelson, K. [0000-0002-4693-8833]
dc.identifier.orcidNewman, M. [0000-0002-4930-4529]
dc.identifier.orcidLardelli, M. [0000-0002-4289-444X]
dc.identifier.urihttps://hdl.handle.net/2440/140171
dc.language.isoen
dc.publisherIOS Press
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1061006
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1045507
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1061006
dc.rights© 2020 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).
dc.source.urihttps://doi.org/10.3233/adr-200177
dc.subjectAlzheimer’s disease
dc.subjectamyloid
dc.subjectamyloid-beta protein precursor
dc.subjectendocytosis
dc.subjectendosomes
dc.subjectprotein transport
dc.titleSorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease
dc.typeJournal article
pubs.publication-statusPublished

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