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Exploring interhemispheric interaction in complex regional pain syndrome

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dc.contributor.authorBerryman, C.
dc.contributor.authorMoseley, G.L.
dc.contributor.authorStanton, T.R.
dc.contributor.authorHordacre, B.
dc.contributor.authorDi Pietro, F.
dc.date.issued2025
dc.description.abstractBackground: Complex regional pain syndrome (CRPS) is characterised by sensorimotor disturbances in the painful limb, coupled with neuroimaging evidence of functional changes in the primary somatosensory cortex (S1). However, the interaction between S1 in both hemispheres is unknown; altered interhemispheric interaction may contribute to this disorder. Objective: We conducted the first study of sensory interhemispheric interaction in CRPS, specifically S1. This is also the first study to compare S1 interhemispheric inhibition in both directions in healthy controls. Methods: Somatosensory evoked potentials were read with electroencephalography following paired median nerve stimulation at interstimulus intervals of 20, 25 and 30 ms. Results: There was an inhibitory effect of the non-dominant on the dominant hemisphere in controls (ß = −0.308, SE 0.089, [CI −0.535, −0.081], t (914.9) = -3.49, p = 0.003), driven by changes in the N20/P25 SEP (i.e. S1). Importantly, this pattern of interhemispheric interaction was not seen in CRPS; in the CRPS group there was no evidence of interhemispheric inhibition – in either direction. Conclusion: Given the difference in interhemispheric inhibition between CRPS and control groups, the role of S1 interhemispheric inhibition in CRPS needs further investigation. This may shed light on the sensorimotor disturbances characteristic of this disorder.
dc.description.statementofresponsibilityC. Berryman, G.L. Moseley, T.R. Stanton, B. Hordacre, F. Di Pietro
dc.identifier.citationNeuroscience Letters, 2025; 847(138100):138100-1-138100-5
dc.identifier.doi10.1016/j.neulet.2024.138100
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.orcidBerryman, C. [0000-0002-5316-0847]
dc.identifier.orcidHordacre, B. [0000-0002-7129-6684]
dc.identifier.urihttps://hdl.handle.net/2440/144832
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1127155
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1178444
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/105404
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1141735
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1125054
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1091415
dc.rights© 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY licensehttp://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.1016/j.neulet.2024.138100
dc.subjectChronic limb pain; Somatosensory evoked potential; EEG; Interhemispheric inhibition; Primary somatosensory cortex
dc.titleExploring interhemispheric interaction in complex regional pain syndrome
dc.typeJournal article
pubs.publication-statusPublished

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