Three cases of BRAF-mutant melanoma with divergent differentiation masquerading as sarcoma.

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dc.contributor.authorCilento, M.A.
dc.contributor.authorKim, C.
dc.contributor.authorChang, S.
dc.contributor.authorFarshid, G.
dc.contributor.authorBrown, M.P.
dc.date.issued2022
dc.description.abstractMelanoma is an important cause of skin cancer related death throughout the world, particularly in Europe, the United States, and Australia. Rarely melanoma undergoes divergent differentiation to simulate the full morphologic and immunohistochemical features of other malignancies, notably sarcoma. However, such cases retain the molecular signatures of melanoma, including BRAF gene mutations. Gene mutation analysis of tumour DNA, now standard practice for all melanomas of stage III or above, may establish the diagnosis of melanoma in some advanced malignancies of unknown lineage. A prior history of melanoma or risk factors for melanoma may be the first clue that an advanced malignancy represents metastatic melanoma. Recognition of this presentation of melanoma can allow a patient to access well-tolerated life-prolonging therapies such as targeted therapy, inhibiting the BRAF/MEK pathway, and immune checkpoint inhibitor therapy.
dc.description.statementofresponsibilityMichael A. Cilento, Chankyung Kim, Sean Chang, Gelareh Farshid, Michael P. Brown
dc.identifier.citationPathologica, 2022; 114(3):217-220
dc.identifier.doi10.32074/1591-951X-771
dc.identifier.issn1591-951X
dc.identifier.issn1591-951X
dc.identifier.orcidCilento, M.A. [0000-0003-2216-5650]
dc.identifier.orcidKim, C. [0000-0001-6054-0605]
dc.identifier.orcidFarshid, G. [0000-0002-2056-0561]
dc.identifier.orcidBrown, M.P. [0000-0002-5796-1932] [0000-0002-6678-1407]
dc.identifier.urihttps://hdl.handle.net/2440/146191
dc.language.isoen
dc.publisherPacini Editore SpA
dc.rights© Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology. Open Access This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons. org/licenses/by-nc-nd/4.0/deed.en
dc.source.urihttps://doi.org/10.32074/1591-951x-771
dc.subjectmelanoma; proto-oncogene proteins B-raf; cell dedifferentiation; oncology; immunotherapy
dc.subject.meshHumans
dc.subject.meshSarcoma
dc.subject.meshMelanoma
dc.subject.meshSkin Neoplasms
dc.subject.meshSoft Tissue Neoplasms
dc.subject.meshProto-Oncogene Proteins B-raf
dc.titleThree cases of BRAF-mutant melanoma with divergent differentiation masquerading as sarcoma.
dc.typeJournal article
pubs.publication-statusPublished

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