Serious kidney disease in pregnancy: An Australian national cohort study protocol

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dc.contributor.authorSafi, N.
dc.contributor.authorSullivan, E.
dc.contributor.authorLi, Z.
dc.contributor.authorBrown, M.
dc.contributor.authorHague, W.
dc.contributor.authorMcDonald, S.
dc.contributor.authorPeek, M.J.
dc.contributor.authorMakris, A.
dc.contributor.authorO'Brien, A.M.
dc.contributor.authorJesudason, S.
dc.date.issued2019
dc.description.abstractBackground: Maternal kidney disease (acute kidney injury (AKI), advanced chronic kidney disease (CKD), dependence on dialysis or a kidney transplant) has a substantial impact on pregnancy, with risks of significant perinatal morbidity. These pregnancies require integrated multidisciplinary care to manage a complex and often challenging clinical situation. The ability to deliver optimal care is currently hindered by a lack of understanding around prevalence, management and outcomes in Australia. This study aims to expand an evidence base to improve clinical care of women with serious kidney impairment in pregnancy. Methods/design: The “Kidney Disease in Pregnancy Study” is a national prospective cohort study of women with stage 3b-5 CKD (including dialysis and transplant) and severe AKI in pregnancy, using the Australasian Maternity Outcomes Surveillance System (AMOSS). AMOSS incorporates Australian maternity units with > 50 births/year (n = 260), capturing approximately 96% of Australian births. We will identify women meeting the inclusion criteria who give birth in Australia between 1st August 2017 and 31st July 2018. Case identification will occur via monthly review of all births in Australian AMOSS sites and prospective notification to AMOSS via renal or obstetric clinics. AMOSS data collectors will capture key clinical data via a web-based data collection tool. The data collected will focus on the prevalence, medical and obstetric clinical care, and maternal and fetal outcomes of these high-risk pregnancies. Discussion: This study will increase awareness of the issue of serious renal impairment in pregnancy through engagement of 260 maternity units and obstetric and renal healthcare providers across the country. The study results will provide an evidence base for pre-pregnancy counselling and development of models of optimal clinical care, clinical guideline and policy development in Australia. Understanding current practices, gaps in care and areas for intervention will improve the care of women with serious renal impairment, women with high-risk pregnancies, their babies and their families.
dc.description.statementofresponsibilityNadom Safi, Elizabeth Sullivan, Zhuoyang Li, Mark Brown, William Hague, Stephen McDonald, Michael J. Peek, Angela Makris, Angela M. O'Brien, and Shilpanjali Jesudason
dc.identifier.citationBMC Nephrology, 2019; 20(1):230-1-230-7
dc.identifier.doi10.1186/s12882-019-1393-z
dc.identifier.issn1471-2369
dc.identifier.issn1471-2369
dc.identifier.orcidHague, W. [0000-0002-5355-2955]
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]
dc.identifier.orcidJesudason, S. [0000-0001-9695-0761]
dc.identifier.urihttps://hdl.handle.net/2440/145929
dc.language.isoen
dc.publisherBMC
dc.rights© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.source.urihttps://doi.org/10.1186/s12882-019-1393-z
dc.subjectCohort study; Population; Pregnancy; Pregnancy outcome; Chronic kidney disease; Acute kidney injury; Kidney transplantation; Renal dialysis
dc.subject.meshHumans
dc.subject.meshKidney Diseases
dc.subject.meshPregnancy Complications
dc.subject.meshGlomerular Filtration Rate
dc.subject.meshSeverity of Illness Index
dc.subject.meshCohort Studies
dc.subject.meshProspective Studies
dc.subject.meshPregnancy
dc.subject.meshAdult
dc.subject.meshAustralia
dc.subject.meshFemale
dc.titleSerious kidney disease in pregnancy: An Australian national cohort study protocol
dc.typeJournal article
pubs.publication-statusPublished

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