A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults

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dc.contributor.authorPham, H.
dc.contributor.authorTrahair, L.
dc.contributor.authorPhillips, L.
dc.contributor.authorRayner, C.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.
dc.date.issued2019
dc.description.abstractBackground: Postprandial hypotension (PPH) occurs frequently in the elderly and patients with type 2 diabetes, and lacks a satisfactory treatment. Gastric distension and the α-glucosidase inhibitor, acarbose, may attenuate the postprandial fall in blood pressure (BP) by complementary mechanisms. We aimed to determine whether gastric distension and acarbose have additive effects to attenuate the fall in BP induced by oral sucrose. Methods: Ten healthy older adults (74.0 ± 1.4 yr) had measurements of BP and superior mesenteric artery (SMA) blood flow for 120 min after receiving either (i) the ‘study drink’ of 100 g sucrose in 300 mL of water (control treatment), (ii) a 300 mL water ‘preload’ 15 min before the ‘study drink’ (distension treatment), (iii) 100 mg acarbose dissolved in the ‘study drink’ (acarbose treatment) or (iv) a 300 ml water ‘preload’ 15 min before 100 mg acarbose dissolved in the ‘study drink’ (acarbose and distension treatment). Results: The area under the curve (AUC)0–120min for mean arterial pressure (MAP) was greater (P = 0.005) and the maximum fall in MAP was less (P = 0.006) during treatments with acarbose. Gastric distension did not affect the MAP-AUC0–120min response to acarbose (P = 0.44) and there was no effect of gastric distension alone (P = 0.68). Both acarbose treatments attenuated the rise in SMA blood flow (P = 0.003), whereas gastric distension had no effect. Conclusions: In healthy older adults, acarbose (100 mg), but not gastric distension, attenuates the fall in BP and rise in SMA blood flow after oral sucrose. The observations support the use of acarbose, but not gastric distension, to attenuate a postprandial fall in BP. Trial registration: The study was retrospectively registered at (ACTRN12618000152224) on February 02nd 2018.
dc.description.statementofresponsibilityHung Pham, Laurence Trahair, Liza Phillips, Christopher Rayner, Michael Horowitz, and Karen Jones
dc.identifier.citationBMC Geriatrics, 2019; 19(1):241-1-241-8
dc.identifier.doi10.1186/s12877-019-1251-7
dc.identifier.issn1471-2318
dc.identifier.issn1471-2318
dc.identifier.orcidPham, H. [0000-0002-7055-3108]
dc.identifier.orcidPhillips, L. [0000-0002-9066-717X]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.urihttps://hdl.handle.net/2440/145928
dc.language.isoen
dc.publisherBMC
dc.rights© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.source.urihttps://doi.org/10.1186/s12877-019-1251-7
dc.subjectPostprandial hypotension; Acarbose; Gastric distension
dc.subject.meshHumans
dc.subject.meshHypotension
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshBlood Glucose
dc.subject.meshSucrose
dc.subject.meshAcarbose
dc.subject.meshCombined Modality Therapy
dc.subject.meshRetrospective Studies
dc.subject.meshCross-Over Studies
dc.subject.meshBlood Pressure
dc.subject.meshHeart Rate
dc.subject.meshPostprandial Period
dc.subject.meshAged
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshGlycoside Hydrolase Inhibitors
dc.subject.meshGastric Absorption
dc.titleA randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults
dc.typeJournal article
pubs.publication-statusPublished

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