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Heritability of Gene Expression Measured from Peripheral Blood in Older Adults

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dc.contributor.authorKanchibhotla, S.C.
dc.contributor.authorMather, K.A.
dc.contributor.authorArmstrong, N.J.
dc.contributor.authorCiobanu, L.G.
dc.contributor.authorBaune, B.T.
dc.contributor.authorCatts, V.S.
dc.contributor.authorSchofield, P.R.
dc.contributor.authorTrollor, J.N.
dc.contributor.authorAmes, D.
dc.contributor.authorSachdev, P.S.
dc.contributor.authorThalamuthu, A.
dc.date.issued2024
dc.description.abstractThe contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies have investigated the heritability of blood gene expression in older adults. The current study therefore aimed to investigate this question in a community sample of older adults. A total of 246 adults (71 MZ and 52 DZ twins, 69.91% females; mean age-75.79 ± 5.44) were studied. Peripheral blood gene expression was assessed using Illumina microarrays. A heritability analysis was performed using structural equation modelling. There were 5269 probes (19.9%) from 4603 unique genes (23.9%) (total 26,537 probes from 19,256 genes) that were significantly heritable (mean h² = 0.40). A pathway analysis of the top 10% of significant genes showed enrichment for the immune response and ageing-associated genes. In a comparison with two other gene expression twin heritability studies using adults from across the lifespan, there were 38 out of 9479 overlapping genes that were significantly heritable. In conclusion, our study found ~24% of the available genes for analysis were heritable in older adults, with only a small number common across studies that used samples from across adulthood, indicating the importance of examining gene expression in older age groups.
dc.description.statementofresponsibilitySri C. Kanchibhotla, Karen A. Mather, Nicola J. Armstrong, Liliana G. Ciobanu, Bernhard T. Baune, Vibeke S. Catts, Peter R. Schofield, Julian N. Trollor, David Ames, Perminder S. Sachdev and Anbupalam Thalamuthu
dc.identifier.citationGenes, 2024; 15(4):495-1-495-13
dc.identifier.doi10.3390/genes15040495
dc.identifier.issn2073-4425
dc.identifier.issn2073-4425
dc.identifier.orcidCiobanu, L.G. [0000-0002-4768-5452]
dc.identifier.orcidBaune, B.T. [0000-0001-6548-426X]
dc.identifier.urihttps://hdl.handle.net/2440/142585
dc.language.isoen
dc.publisherMDPI
dc.relation.granthttp://purl.org/au-research/grants/arc/401162
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1024224
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1025243
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1045325
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1085606
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1060524
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/568969
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1093083
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttps://doi.org/10.3390/genes15040495
dc.subjectgene expression; older adults; twins; heritability
dc.subject.meshHumans
dc.subject.meshGene Expression
dc.subject.meshAging
dc.subject.meshTwins, Dizygotic
dc.subject.meshTwins, Monozygotic
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshFemale
dc.subject.meshMale
dc.titleHeritability of Gene Expression Measured from Peripheral Blood in Older Adults
dc.typeJournal article
pubs.publication-statusPublished

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