A fixel-based analysis of micro- and macro-structural changes to white matter following adult traumatic brain injury

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dc.contributor.authorWallace, E.J.
dc.contributor.authorMathias, J.L.
dc.contributor.authorWard, L.
dc.contributor.authorFripp, J.
dc.contributor.authorRose, S.
dc.contributor.authorPannek, K.
dc.date.issued2020
dc.descriptionFirst published: 30 January 2020
dc.description.abstractDiffusion tensor imaging is often used to assess white matter (WM) changes following traumatic brain injury (TBI), but is limited in voxels that contain multiple fibre tracts. Fixel-based analysis (FBA) addresses this limitation by using a novel method of analysing high angular resolution diffusion-weighted imaging (HARDI) data. FBA examines three aspects of each fibre tract within a voxel: tissue micro-structure (fibre density [FD]), tissue macro-structure (fibre-bundle cross section [FC]) and a combined measure of both (FD and fibre-bundle cross section [FDC]). This study used FBA to identify the location and extent of micro- and macro-structural changes in WM following TBI. A large TBI sample (Nmild = 133, Nmoderate-severe = 29) and control group (healthy and orthopaedic; N = 107) underwent magnetic resonance imaging with HARDI and completed reaction time tasks approximately 7 months after their injury (range: 98-338 days). The TBI group showed micro-structural differences (lower FD) in the corpus callosum and forceps minor, compared to controls. Subgroup analyses revealed that the mild TBI group did not differ from controls on any fixel metric, but the moderate to severe TBI group had significantly lower FD, FC and FDC in multiple WM tracts, including the corpus callosum, cerebral peduncle, internal and external capsule. The moderate to severe TBI group also had significantly slower reaction times than controls, but the mild TBI group did not. Reaction time was not related to fixel findings. Thus, the WM damage caused by moderate to severe TBI manifested as fewer axons and a reduction in the cross-sectional area of key WM tracts.
dc.description.statementofresponsibilityErica J. Wallace, Jane L. Mathias, Lynn Ward, Jurgen Fripp, Stephen Rose, Kerstin Pannek
dc.identifier.citationHuman Brain Mapping, 2020; 41(8):2187-2197
dc.identifier.doi10.1002/hbm.24939
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193
dc.identifier.orcidMathias, J.L. [0000-0001-8957-8594]
dc.identifier.urihttp://hdl.handle.net/2440/123222
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/519220
dc.rights© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
dc.source.urihttps://doi.org/10.1002/hbm.24939
dc.subjectCorpus Callosum
dc.subjectInternal Capsule
dc.subjectHumans
dc.subjectBrain Concussion
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectGlasgow Coma Scale
dc.subjectFollow-Up Studies
dc.subjectReaction Time
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectWhite Matter
dc.subjectExternal Capsule
dc.subjectCerebral Peduncle
dc.subjectBrain Injuries, Traumatic
dc.titleA fixel-based analysis of micro- and macro-structural changes to white matter following adult traumatic brain injury
dc.typeJournal article
pubs.publication-statusPublished

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