Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation

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dc.contributor.authorDenton, D.
dc.contributor.authorXu, T.
dc.contributor.authorDayan, S.
dc.contributor.authorNicolson, S.
dc.contributor.authorKumar, S.
dc.date.issued2019
dc.description.abstractThe majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicle for delivery to the lysosome. An established model for autophagy-dependent PCD is Drosophila larval midgut removal during metamorphosis. Our previous work demonstrated that growth arrest is required to initiate autophagy-dependent midgut degradation and Target of rapamycin (Tor) limits autophagy induction. In further studies, we uncovered a role for Decapentaplegic (Dpp) in coordinating midgut degradation. Here, we provide new data to show that Dpp interacts with Tor during midgut degradation. Inhibiting Tor rescued the block in midgut degradation due to Dpp signaling. We propose that Dpp is upstream of Tor and down-regulation promotes growth arrest and autophagy-dependent midgut degradation. These findings underscore a relationship between Dpp and Tor signaling in the regulation of cell growth and tissue removal.
dc.description.statementofresponsibilityDonna Denton, Tianqi Xu, Sonia Dayan, Shannon Nicolson and Sharad Kumar
dc.identifier.citationCell Death and Disease, 2019; 10(2):111-1-111-8
dc.identifier.doi10.1038/s41419-019-1368-9
dc.identifier.issn2041-4889
dc.identifier.issn2041-4889
dc.identifier.orcidXu, T. [0000-0003-2550-9869]
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]
dc.identifier.urihttp://hdl.handle.net/2440/118423
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041807
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1124490
dc.relation.granthttp://purl.org/au-research/grants/arc/DP170100623
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1103006
dc.rights© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1038/s41419-019-1368-9
dc.subjectDigestive System
dc.subjectAnimals
dc.subjectDrosophila
dc.subjectDrosophila Proteins
dc.subjectSignal Transduction
dc.subjectLarva
dc.subjectAutophagy
dc.subjectGene Knockdown Techniques
dc.subjectTOR Serine-Threonine Kinases
dc.titleCrosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation
dc.typeJournal article
pubs.publication-statusPublished

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