Effect of swirling flow and particle-release pattern on drug delivery to human tracheobronchial airways

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dc.contributor.authorTaheri, M.H.
dc.contributor.authorPourmehran, O.
dc.contributor.authorSarafraz, M.M.
dc.contributor.authorAhookhosh, K.
dc.contributor.authorFarnoud, A.
dc.contributor.authorCui, X.
dc.date.issued2021
dc.description.abstractThe present study aims to investigate the effect of swirling flow on particle deposition in a realistic human airway. A computational fluid dynamic (CFD) model was utilized for the simulation of oral inhalation and particle transport patterns, considering the k-omega turbulence model. Lagrangian particle tracking was used to track the particles' trajectories. A normal breathing condition (30 L/min) was applied, and two-micron particles were injected into the mouth, considering swirling flow to the oral inhalation airflow. Different cases were considered for releasing the particles, which evaluated the impacts of various parameters on the deposition efficiency (DE), including the swirl intensity, injection location and pattern of the particle. The work's novelty is applying several injection locations and diameters simultaneously. The results show that the swirling flow enhances the particle deposition efficiency (20-40%) versus no-swirl flow, especially in the mouth. However, releasing particles inside the mouth, or injecting them randomly with a smaller injection diameter (dinj) reduced DE in swirling flow condition, about 50 to 80%. Injecting particles inside the mouth can decrease DE by about 20%, and releasing particles with smaller dinj leads to 50% less DE in swirling flow. In conclusion, it is indicated that the airflow condition is an important parameter for a reliable drug delivery, and it is more beneficial to keep the inflow uniform and avoid swirling flow.
dc.description.statementofresponsibilityMohammad Hasan Taheri, Oveis Pourmehran, Mohammad Mohsen Sarafraz, Keveh Ahookhosh, Ali Farnoud, Xinguang Cui
dc.identifier.citationBiomechanics and Modeling in Mechanobiology, 2021; 20(6):2451-2469
dc.identifier.doi10.1007/s10237-021-01518-5
dc.identifier.issn1617-7940
dc.identifier.issn1617-7940
dc.identifier.orcidPourmehran, O. [0000-0002-9564-2772]
dc.identifier.urihttps://hdl.handle.net/2440/146264
dc.language.isoen
dc.publisherSpringer (part of Springer Nature)
dc.rights© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021
dc.source.urihttps://doi.org/10.1007/s10237-021-01518-5
dc.subjectComputational fluid dynamics (CFD); Deposition efficiency; Discrete phase model (DPM); Drug delivery; Swirling flow
dc.subject.meshMouth
dc.subject.meshBronchi
dc.subject.meshTrachea
dc.subject.meshHumans
dc.subject.meshDrug Delivery Systems
dc.subject.meshInjections
dc.subject.meshRheology
dc.subject.meshMiddle Aged
dc.subject.meshFemale
dc.titleEffect of swirling flow and particle-release pattern on drug delivery to human tracheobronchial airways
dc.typeJournal article
pubs.publication-statusPublished

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