Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2

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dc.contributor.authorGroth, C.
dc.contributor.authorNornes, S.
dc.contributor.authorMc Carty, R.
dc.contributor.authorTamme, R.
dc.contributor.authorLardelli, M.
dc.contributor.organisationCentre for the Molecular Genetics of Development
dc.date.issued2002
dc.description© Springer-Verlag 2002 The original publication can be found at www.springerlink.com
dc.description.abstractPresenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
dc.description.statementofresponsibilityCasper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli
dc.identifier.citationDevelopment Genes and Evolution, 2002; 212(10):486-490
dc.identifier.doi10.1007/s00427-002-0269-5
dc.identifier.issn0949-944X
dc.identifier.issn1432-041X
dc.identifier.orcidLardelli, M. [0000-0002-4289-444X]
dc.identifier.urihttp://hdl.handle.net/2440/28202
dc.language.isoen
dc.publisherSpringer
dc.source.urihttp://www.springerlink.com/content/pne2xqatmd1kjga5/
dc.subjectPresenilin
dc.subjectNeural crest
dc.subjectZebrafish
dc.subjectAlzheimer’s disease
dc.subjectMelanocyte
dc.titleIdentification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
dc.typeJournal article
pubs.publication-statusPublished

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