Control of gene expression in the temperate coliphage 186. X. The cl repressor directly represses transcription of the late control gene B
Date
1992
Authors
Dibbens, J.A.
Gregory, S.L.
Egan, J.B.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Molecular Microbiology, 1992; 6(18):2643-2650
Statement of Responsibility
Justin A. Dibbens, Stephen L. Gregory and J. Barry Egan
Conference Name
Abstract
We have found that the repressor of 186 lytic transcription, CI, represses transcription of the late control gene B, with no involvement of the B protein Itself. In clone studies we showed that CI repressed transcription from the B promoter and that temperature inactivation of CIts led to B derepression. We conclude that CI repressor directly represses transcription of the Bgene and, with prophage induction, it is probable that the inactivation of the CI repressor not only derepresses early lytic transcription, but also derepresses B gene transcription, leading to the activation of transcription from the late promoters.