Does vitamin D deficiency contribute to endothelial dysfunction? /
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(Published version)
Date
2014
Authors
Amarasekera, Anjalee Thanuja Nilanganee,
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thesis
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Abstract
Vitamin D deficiency and high parathyroid hormone (PTH) levels have been associated with increased cardiovascular (CV) events. The study with obese-diabetic subjects showed that PTH levels could be a coronary risk factor because they have a positive correlation with plasma asymmetric dimethylarginine (ADMA; a biomarker of CV events) independent from vitamin D levels. In this research we showed for the first time that vitamin D levels were negatively associated with another marker of CV risk, thrombospondin-1 (TSP-1) in healthy adults. The vitamin D intervention in deficient adults reduced TSP-1 levels by almost 2-fold, independent of changes in PTH. The studies conducted both in healthy and obese-diabetic subjects confirmed that low vitamin D and high PTH levels could be CV risk factors. The correction of low vitamin D levels with vitamin D supplementation could minimize the CV risk from altered vitamin D and PTH levels.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD)--University of South Australia, 2014.
Provenance
Copyright 2014 Anjalee Amarasekera.
Description
1 ethesis (219 pages) :
illustrations (some colour).
Includes bibliographical references (leaves 161-192)
illustrations (some colour).
Includes bibliographical references (leaves 161-192)
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