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Does vitamin D deficiency contribute to endothelial dysfunction? /

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dc.contributor.authorAmarasekera, Anjalee Thanuja Nilanganee,
dc.contributor.schoolUniversity of South Australia. School of Pharmacy and Medical Sciences.
dc.contributor.schoolSchool of Pharmacy and Medical Sciences.
dc.date.issued2014
dc.description1 ethesis (219 pages) :
dc.descriptionillustrations (some colour).
dc.descriptionIncludes bibliographical references (leaves 161-192)
dc.description.abstractVitamin D deficiency and high parathyroid hormone (PTH) levels have been associated with increased cardiovascular (CV) events. The study with obese-diabetic subjects showed that PTH levels could be a coronary risk factor because they have a positive correlation with plasma asymmetric dimethylarginine (ADMA; a biomarker of CV events) independent from vitamin D levels. In this research we showed for the first time that vitamin D levels were negatively associated with another marker of CV risk, thrombospondin-1 (TSP-1) in healthy adults. The vitamin D intervention in deficient adults reduced TSP-1 levels by almost 2-fold, independent of changes in PTH. The studies conducted both in healthy and obese-diabetic subjects confirmed that low vitamin D and high PTH levels could be CV risk factors. The correction of low vitamin D levels with vitamin D supplementation could minimize the CV risk from altered vitamin D and PTH levels.
dc.description.dissertationThesis (PhD)--University of South Australia, 2014.
dc.identifier.urihttps://hdl.handle.net/11541.2/123495
dc.language.isoen
dc.provenanceCopyright 2014 Anjalee Amarasekera.
dc.subject.lcshCardiovascular system
dc.subject.lcshParathyroid hormone.
dc.subject.lcshVitamin D Deficiency
dc.titleDoes vitamin D deficiency contribute to endothelial dysfunction? /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12146654150001831 13146650920001831 9916110103701831_53140664020001831.pdf
ror.mmsid9916110103701831

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