Hidden secrets of sigma54 promoters revealed
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2017
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Hao, N.
Shearwin, K.E.
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Trends in Biochemical Sciences, 2017; 42(12):931-932
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Nan Hao and Keith E. Shearwin
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Abstract
Bacterial sigma54 (σ⁵⁴) promoters are the DNA-binding motif for σ⁵⁴-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ⁵⁴ promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation.
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© 2017 Elsevier Ltd. All rights reserved.