Hidden secrets of sigma54 promoters revealed
| dc.contributor.author | Hao, N. | |
| dc.contributor.author | Shearwin, K.E. | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Bacterial sigma54 (σ⁵⁴) promoters are the DNA-binding motif for σ⁵⁴-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinformatics has uncovered a new and unexpected role for σ⁵⁴ promoters, encoding a form of bacterial 'insulator sequence' to dampen unwanted translation. | |
| dc.description.statementofresponsibility | Nan Hao and Keith E. Shearwin | |
| dc.identifier.citation | Trends in Biochemical Sciences, 2017; 42(12):931-932 | |
| dc.identifier.doi | 10.1016/j.tibs.2017.10.005 | |
| dc.identifier.issn | 0968-0004 | |
| dc.identifier.issn | 1362-4326 | |
| dc.identifier.orcid | Hao, N. [0000-0001-5836-3507] | |
| dc.identifier.orcid | Shearwin, K.E. [0000-0002-7736-2742] | |
| dc.identifier.uri | http://hdl.handle.net/2440/124218 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.rights | © 2017 Elsevier Ltd. All rights reserved. | |
| dc.source.uri | https://doi.org/10.1016/j.tibs.2017.10.005 | |
| dc.subject | DNA-Directed RNA Polymerases | |
| dc.title | Hidden secrets of sigma54 promoters revealed | |
| dc.type | Journal article | |
| pubs.publication-status | Published |
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