Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

Date

2010

Authors

Hale, K.
Manaviazar, S.
George, J.

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Advisors

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Volume Title

Type:

Journal article

Citation

Chemical Communications, 2010; 46(23):4021-4042

Statement of Responsibility

Karl J. Hale, Soraya Manaviazar and Jonathan George

Conference Name

DOI

10.1039/C000603C

Abstract

Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

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Dissertation Note

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This journal is copyright The Royal Society of Chemistry 2010

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Published Version

https://doi.org/10.1039/c000603c

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Persistent link to this record

http://hdl.handle.net/2440/68553