Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

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dc.contributor.authorHale, K.
dc.contributor.authorManaviazar, S.
dc.contributor.authorGeorge, J.
dc.date.issued2010
dc.description.abstractHerein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.
dc.description.statementofresponsibilityKarl J. Hale, Soraya Manaviazar and Jonathan George
dc.identifier.citationChemical Communications, 2010; 46(23):4021-4042
dc.identifier.doi10.1039/C000603C
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.orcidGeorge, J. [0000-0002-7330-2160]
dc.identifier.urihttp://hdl.handle.net/2440/68553
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.rightsThis journal is copyright The Royal Society of Chemistry 2010
dc.source.urihttps://doi.org/10.1039/c000603c
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectColonic Neoplasms
dc.subjectDepsipeptides
dc.subjectPeptides
dc.subjectTranscription Factors
dc.subjectTranscription, Genetic
dc.subjectE2F Transcription Factors
dc.subjectbeta Catenin
dc.subjectBasic Helix-Loop-Helix Leucine Zipper Transcription Factors
dc.subjectTranscription Factor 4
dc.titleTotal synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription
dc.title.alternativeTotal synthesis of (+) - A83586C, (+)- kettapeptin and (+)- azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription
dc.typeJournal article
pubs.publication-statusPublished

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