Peri-conceptual cytokines - Setting the trajectory for embryo implantation, pregnancy and beyond
| dc.contributor.author | Robertson, S. | |
| dc.contributor.author | Chin, P. | |
| dc.contributor.author | Glynn, D. | |
| dc.contributor.author | Thompson, J. | |
| dc.date.issued | 2011 | |
| dc.description.abstract | <h4>Problem</h4>The peri-conceptual environment influences the early embryo to impart long-term consequences for the fetus and neonate; however, the underlying mechanisms are not well defined.<h4>Method of study</h4>We argue that the cytokine network acting in the female reproductive tract during the pre- and peri-implantation period integrates environmental information to program the embryo and fine-tune the maternal immune response and endometrial remodelling to determine implantation success.<h4>Results</h4>As well as sex steroid hormones and male seminal fluid factors, female tract cytokines are influenced by agents signalling via the Toll-like receptors including the microbiome and a plethora of metabolic, chemical and other stressors. In mouse models, an altered peri-conceptual cytokine environment induced by cytokine deficiency, inflammatory insults or dysregulated seminal fluid signalling is associated with adverse effects on embryo development, pregnancy viability and reproductive outcome.<h4>Conclusion</h4>The cytokine network provides a pivotal mechanism through which environmental factors influence both embryo development and receptivity of the uterus. | |
| dc.description.statementofresponsibility | Sarah A. Robertson, Peck Yin Chin, Danielle J. Glynn, Jeremy G. Thompson | |
| dc.identifier.citation | American Journal of Reproductive Immunology, 2011; 66(Suppl 1):2-10 | |
| dc.identifier.doi | 10.1111/j.1600-0897.2011.01039.x | |
| dc.identifier.issn | 1046-7408 | |
| dc.identifier.issn | 1600-0897 | |
| dc.identifier.orcid | Robertson, S. [0000-0002-9967-0084] | |
| dc.identifier.orcid | Chin, P. [0000-0002-0923-0553] | |
| dc.identifier.orcid | Thompson, J. [0000-0003-4941-7731] | |
| dc.identifier.uri | http://hdl.handle.net/2440/65987 | |
| dc.language.iso | en | |
| dc.publisher | Wiley-Blackwell Publishing, Inc | |
| dc.rights | © 2011 John Wiley & Sons A/S | |
| dc.source.uri | https://doi.org/10.1111/j.1600-0897.2011.01039.x | |
| dc.subject | Cytokines | |
| dc.subject | embryo | |
| dc.subject | implantation | |
| dc.subject | infertility | |
| dc.subject | pregnancy | |
| dc.subject | programming | |
| dc.title | Peri-conceptual cytokines - Setting the trajectory for embryo implantation, pregnancy and beyond | |
| dc.type | Journal article | |
| pubs.publication-status | Published |