Impact of COVID-19 Containment Strategies and Meningococcal Conjugate ACWY Vaccination on Meningococcal Carriage in Adolescents

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dc.contributor.authorMcMillan, M.
dc.contributor.authorBednarz, J.
dc.contributor.authorLeong, L.E.X.
dc.contributor.authorLawrence, A.
dc.contributor.authorMarshall, H.S.
dc.date.issued2022
dc.descriptionVaccine Reports.
dc.description.abstractOBJECTIVES: To examine if COVID-19 containment strategies were associated with reduced pharyngeal carriage of meningococci in adolescents. Also, to observe if carriage prevalence of meningococcal A, C, W and Y differed in meningococcal conjugate ACWY vaccinated and unvaccinated adolescents. DESIGN: Repeat cross-sectional study of pharyngeal carriage. SETTING: In 2020, recruitment commenced from February to March (pre-COVID-19) and recommenced from August to September (during COVID-19 measures) in South Australia. PARTICIPANTS: Eligible participants were between 17 and 25 years of age and completed secondary school in South Australia in 2019. RESULTS: A total of 1338 school leavers were enrolled in 2020, with a mean age of 18.6 years (standard deviation 0.6). Pharyngeal carriage of disease-associated meningococci was higher during the COVID-19 period compared with the pre-COVID-19 period (41/600 [6.83%] vs. 27/738 [3.66%]; adjusted odds ratio [aOR], 2.03; 95% CI: 1.22-3.39; P = 0.01). Nongroupable carriage decreased during COVID period (1.67% vs. 3.79%; aOR, 0.45; 95% CI: 0.22-0.95). Pharyngeal carriage of groups A, C, W and Y was similar among school leavers vaccinated with meningococcal conjugate ACWY (7/257 [2.72%]) compared with those unvaccinated (29/1081 [2.68%]; aOR, 0.86; 95% CI: 0.37-2.02; P = 0.73). Clonal complex 41/44 predominated in both periods. CONCLUSIONS: Meningococcal carriage prevalence was not impacted by public health strategies to reduce severe acute respiratory syndrome coronavirus 2 transmission and is unlikely to be the mechanism for lower meningococcal disease incidence. As international travel resumes and influenza recirculates, clinicians must remain vigilant for signs and symptoms of meningococcal disease. Vaccinating people at the highest risk of invasive meningococcal disease remains crucial despite containment strategies.
dc.description.statementofresponsibilityMark McMillan, Jana Bednarz, Lex E.X. Leong, Andrew Lawrence, and Helen S. Marshall
dc.identifier.citationPediatric Infectious Disease Journal, 2022; 41(11):e468-e474
dc.identifier.doi10.1097/INF.0000000000003660
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.orcidMcMillan, M. [0000-0002-6490-7707]
dc.identifier.orcidBednarz, J. [0000-0002-5517-1638]
dc.identifier.orcidMarshall, H.S. [0000-0003-2521-5166]
dc.identifier.urihttps://hdl.handle.net/2440/136881
dc.language.isoen
dc.publisherLippincott, Williams & Wilkins
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1155066
dc.rightsCopyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1097/inf.0000000000003660
dc.subjectmeningococcal; carriage; COVID-19
dc.subject.meshHumans
dc.subject.meshNeisseria meningitidis
dc.subject.meshMeningococcal Infections
dc.subject.meshMeningococcal Vaccines
dc.subject.meshVaccination
dc.subject.meshCross-Sectional Studies
dc.subject.meshCarrier State
dc.subject.meshAdolescent
dc.subject.meshCOVID-19
dc.titleImpact of COVID-19 Containment Strategies and Meningococcal Conjugate ACWY Vaccination on Meningococcal Carriage in Adolescents
dc.typeJournal article
pubs.publication-statusPublished

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