Prognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS-

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dc.contributor.authorSuda, A.
dc.contributor.authorTakahashi, J.
dc.contributor.authorSchwidder, M.
dc.contributor.authorOng, P.
dc.contributor.authorAng, D.
dc.contributor.authorBerry, C.
dc.contributor.authorCamici, P.G.
dc.contributor.authorCrea, F.
dc.contributor.authorCarlos Kaski, J.
dc.contributor.authorPepine, C.
dc.contributor.authorRimoldi, O.
dc.contributor.authorSechtem, U.
dc.contributor.authorYasuda, S.
dc.contributor.authorBeltrame, J.F.
dc.contributor.authorNoel Bairey Merz, C.
dc.contributor.authorShimokawa, H.
dc.date.issued2022
dc.description.abstractBackgroud: The aim of this study was to assess the prognostic association of plasma levels of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) with clinical outcomes of patients with microvascular angina (MVA). Methods: In this international prospective cohort study of MVA by the Coronary Vasomotor Disorders International Study (COVADIS) group, we examined the association between plasma NT-proBNP levels and the incidence of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and hospitalization due to heart failure or unstable angina. Results: We examined a total of 226 MVA patients (M/F 66/160, 61.9 ± 10.2 [SD] yrs.) with both plasma NT-proBNP levels and echocardiography data available at the time of enrolment. The median level of NT-proBNP level was 94 pg/ ml, while mean left ventricular ejection fraction was 69.2 ± 10.9 % and E/e’ 10.7 ± 5.2. During follow-up period of a median of 365 days (IQR 365–482), 29 MACEs occurred. Receiver-operating characteristics curve analysis identified plasma NT-proBNP level of 78 pg/ml as the optimal cut-off value. Multivariable logistic regression analysis revealed that plasma NT-proBNP level ≥ 78 pg/ml significantly correlated with the incidence of MACE (odds ratio (OR) [95 % confidence interval (CI)] 3.11[1.14–8.49], P = 0.001). Accordingly, Kaplan-Meier survival analysis showed a significantly worse prognosis in the group with NT-proBNP ≥ 78 (log-rank test, P < 0.03). Finally, a significant positive correlation was observed between plasma NT-proBNP levels and E/e’ (R = 0.445, P < 0.0001). Conclusions: These results indicate that plasma NT-proBNP levels may represent a novel prognostic biomarker for MVA patients.
dc.description.statementofresponsibilityAkira Suda, Jun Takahashi, Maike Schwidder, Peter Ong, Daniel Ang, Colin Berry, Paolo G. Camici, Filippo Crea, Juan Carlos Kaski, Carl Pepine, Ornella Rimoldi, Udo Sechtem, Satoshi Yasuda, John F. Beltrame, C. Noel Bairey Merz, Hiroaki Shimokawa, on behalf of the Coronary Vasomotor Disorders International Study COVADIS Group.
dc.identifier.citationInternational Journal of Cardiology: Heart & Vasculature, 2022; 43:101139-1-101139-7
dc.identifier.doi10.1016/j.ijcha.2022.101139
dc.identifier.issn2352-9067
dc.identifier.issn2352-9067
dc.identifier.orcidBeltrame, J.F. [0000-0002-4294-6510]
dc.identifier.urihttps://hdl.handle.net/2440/146110
dc.language.isoen
dc.publisherElsevier BV
dc.relation.grantU0164829
dc.rights© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.1016/j.ijcha.2022.101139
dc.subjectMicrovascular angina; Brain natriuretic peptides; NT-proBNP; Prognosis.
dc.titlePrognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS-
dc.typeJournal article
pubs.publication-statusPublished

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