Biofilm and osteitis in refractory chronic rhinosinusitis

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dc.contributor.authorZhao, Y.
dc.contributor.authorWormald, P.
dc.date.issued2017
dc.description.abstractOur understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease's pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent. Surgery remains the mainstay treatment for biofilm and osteitis with mechanical disruption and removal of disease load providing the most effective treatment.
dc.description.statementofresponsibilityYi Chen Zhao and Peter-John Wormald
dc.identifier.citationOtolaryngologic Clinics of North America, 2017; 50(1):49-60
dc.identifier.doi10.1016/j.otc.2016.08.005
dc.identifier.issn0030-6665
dc.identifier.issn1557-8259
dc.identifier.orcidWormald, P. [0000-0001-7753-7277]
dc.identifier.urihttp://hdl.handle.net/2440/116018
dc.language.isoen
dc.publisherElsevier
dc.rights© 2016 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.otc.2016.08.005
dc.subjectBiofilm; osteitis; refractory rhinosinusitis; endoscopic surgery
dc.titleBiofilm and osteitis in refractory chronic rhinosinusitis
dc.typeJournal article
pubs.publication-statusPublished

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